# Ionis Pharmaceuticals (IONS) — Overview

IONS · NASDAQ · Stock

Canonical page: https://www.lighthorse.io/tickers/ions

## Price

Last close $44.12 on Oct 15, 2026. 52-week range $42.38 – $86.50.

## Company profile

Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and Biogen brought Spinraza to market in 2016 as a treatment for spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019). Ionis and AstraZeneca launched polyneuropathy drug Wainua in 2024. Ionis marked its first two independent launches in 2025 for Tryngolza (for FCS) and Dawnzera (for HAE).

## Financials

| Metric | Value |
| --- | --- |
| Revenue (trailing twelve months) | $874.1M |
| Revenue (quarter) | $267.9M |
| Revenue growth (year over year) | -40.73% |
| Gross profit (trailing twelve months) | $858.1M |
| Gross margin | 98.17% |
| Net income (trailing twelve months) | −$565.2M |
| Net income (quarter) | −$114.6M |
| Net income growth (year over year) | -192.79% |
| Net margin | -64.66% |
| Return on equity | -105.50% |
| EPS (trailing twelve months) | −$3.48 |
| Book value per share | $2.65 |
| P/E (trailing twelve months) | — |
| Price to book | 16.7 |
| Debt to assets | 85.32% |
| Payout ratio | 0.00% |
| Dividend yield | 0.00% |

## Frequently Asked Questions

### Is Ionis Pharmaceuticals (IONS) profitable?

No. Ionis Pharmaceuticals reported a net loss of $565.2M over the trailing twelve months.

### How much revenue does Ionis Pharmaceuticals (IONS) make?

Ionis Pharmaceuticals generated $874.1M in revenue over the trailing twelve months, down 40.73% year over year.

### How do I buy stock in Ionis Pharmaceuticals (IONS)?

IONS trades commission-free with a Light Horse Securities brokerage account — from the mobile app, the web at [Light Horse Dashboard](https://portal.lighthorse.io), the trading API, or an [AI agent connected over MCP](/instructions/ai/claude). The trade panel on this page places the order once you are signed in.

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Data provided by [AInvest](https://www.ainvest.com).