# Septerna (SEPN) — Overview

SEPN · NASDAQ · Stock

Canonical page: https://www.lighthorse.io/tickers/sepn

## Price

Last close $37.45 on Oct 15, 2026. 52-week range $18.10 – $48.19.

## Company profile

Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.

## Financials

| Metric | Value |
| --- | --- |
| Revenue (trailing twelve months) | $98.9M |
| Revenue (quarter) | $26.7M |
| Revenue growth (year over year) | 22375.63% |
| Gross profit (trailing twelve months) | $98.9M |
| Gross margin | 100.00% |
| Net income (trailing twelve months) | −$24.2M |
| Net income (quarter) | −$13.0M |
| Net income growth (year over year) | 47.52% |
| Net margin | -24.51% |
| Return on equity | -6.34% |
| EPS (trailing twelve months) | −$0.53 |
| Book value per share | $8.47 |
| P/E (trailing twelve months) | — |
| Price to book | 4.5 |
| Debt to assets | 31.76% |
| Payout ratio | 0.00% |
| Dividend yield | 0.00% |

## Frequently Asked Questions

### Is Septerna (SEPN) profitable?

No. Septerna reported a net loss of $24.2M over the trailing twelve months.

### How much revenue does Septerna (SEPN) make?

Septerna generated $98.9M in revenue over the trailing twelve months, up 22375.63% year over year.

### How do I buy stock in Septerna (SEPN)?

SEPN trades commission-free with a Light Horse Securities brokerage account — from the mobile app, the web at [Light Horse Dashboard](https://portal.lighthorse.io), the trading API, or an [AI agent connected over MCP](/instructions/ai/claude). The trade panel on this page places the order once you are signed in.

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Data provided by [AInvest](https://www.ainvest.com).