# Spruce (SPRB) — Overview

SPRB · NASDAQ · Stock

Canonical page: https://www.lighthorse.io/tickers/sprb

## Price

Last close $41.47 on Oct 15, 2026. 52-week range $38.98 – $159.06.

## Company profile

Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.

## Financials

| Metric | Value |
| --- | --- |
| Revenue (trailing twelve months) | $0.00 |
| Revenue (quarter) | $0.00 |
| Revenue growth (year over year) | 0.00% |
| Gross profit (trailing twelve months) | $0.00 |
| Gross margin | 0.00% |
| Net income (trailing twelve months) | $0.00 |
| Net income (quarter) | −$16.2M |
| Net income growth (year over year) | -685.15% |
| Net margin | 0.00% |
| Return on equity | -105.98% |
| EPS (trailing twelve months) | −$38.43 |
| Book value per share | $30.42 |
| P/E (trailing twelve months) | — |
| Price to book | 1.4 |
| Debt to assets | 18.59% |
| Payout ratio | 0.00% |
| Dividend yield | 0.00% |

## Frequently Asked Questions

### How do I buy stock in Spruce (SPRB)?

SPRB trades commission-free with a Light Horse Securities brokerage account — from the mobile app, the web at [Light Horse Dashboard](https://portal.lighthorse.io), the trading API, or an [AI agent connected over MCP](/instructions/ai/claude). The trade panel on this page places the order once you are signed in.

---

Quotes and charts are not real-time and must not be relied on for trade decisions or valuation.

This page is for informational purposes only. Nothing on it is a recommendation, solicitation or offer to buy or sell any security, nor investment, legal or tax advice. Light Horse Securities Inc does not verify third-party data and is not responsible for its accuracy, completeness or timeliness.

Data provided by [AInvest](https://www.ainvest.com).