# Xilio Therapeutics (XLO) — Overview

XLO · NASDAQ · Stock

Canonical page: https://www.lighthorse.io/tickers/xlo

## Price

Last close $9.02 on Oct 15, 2026. 52-week range $7.14 – $11.90.

## Company profile

Xilio Therapeutics Inc is a clinical-stage biotechnology company focused on discovering and developing masked immuno-oncology (I-O) therapies to improve outcomes for people living with cancer. Leveraging its clinically validated masking technology and capabilities, the company develops I-O therapies designed to selectively activate within the tumor microenvironment to achieve durable efficacy without the severe side effects associated with systemically active I-O agents. Its integrated biology and protein engineering approach enables the design and development of potent masked biologics that are activated by tumor-specific proteases.

## Financials

| Metric | Value |
| --- | --- |
| Revenue (trailing twelve months) | $64.1M |
| Revenue (quarter) | $18.7M |
| Revenue growth (year over year) | 131.22% |
| Gross profit (trailing twelve months) | $64.1M |
| Gross margin | 100.00% |
| Net income (trailing twelve months) | −$21.8M |
| Net income (quarter) | −$6.4M |
| Net income growth (year over year) | 59.78% |
| Net margin | -34.06% |
| Return on equity | -55.03% |
| EPS (trailing twelve months) | −$0.32 |
| Book value per share | $10.98 |
| P/E (trailing twelve months) | — |
| Price to book | 0.8 |
| Debt to assets | 53.15% |
| Payout ratio | 0.00% |
| Dividend yield | 0.00% |

## Frequently Asked Questions

### Is Xilio Therapeutics (XLO) profitable?

No. Xilio Therapeutics reported a net loss of $21.8M over the trailing twelve months.

### How much revenue does Xilio Therapeutics (XLO) make?

Xilio Therapeutics generated $64.1M in revenue over the trailing twelve months, up 131.22% year over year.

### How do I buy stock in Xilio Therapeutics (XLO)?

XLO trades commission-free with a Light Horse Securities brokerage account — from the mobile app, the web at [Light Horse Dashboard](https://portal.lighthorse.io), the trading API, or an [AI agent connected over MCP](/instructions/ai/claude). The trade panel on this page places the order once you are signed in.

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Data provided by [AInvest](https://www.ainvest.com).